Are you curious about where the best manufacturing happens in China? With thousands of factories to choose from, finding the right one can feel overwhelming. Understanding the top 1118 factories not only helps you make informed decisions but also ensures quality, efficiency, and cost-effectiveness for your projects. Imagine the peace of mind that comes with knowing you’ve partnered with the best in the business. Ready to discover which factories stand out from the crowd? Dive into our comprehensive comparison and unlock the secrets to successful manufacturing in China!
Fidaxomicin and OP-1118 Inhibit Clostridium difficile Toxin A- and B …
Fidaxomicin and OP-1118 Inhibit Clostridium difficile Toxin A- and B …
Product Details: Fidaxomicin and its primary metabolite OP-1118 are macrolide antibiotics effective against Clostridium difficile infections.
Technical Parameters:
– MIC range of fidaxomicin: approximately 0.001 to 1 μg/ml
– MIC range of OP-1118: around 0.25 to 2 μg/ml
Application Scenarios:
– Treatment of Clostridium difficile infections
– Reduction of inflammatory responses in the human colon
Pros:
– Associated with reduced rates of CDI relapse
– Inhibits toxin A- and B-mediated inflammatory responses and tissue damage
Cons:
– Poorly absorbed in the gastrointestinal tract
– Potential for limited effectiveness against certain strains
Product Details: Fidaxomicin and OP-1118
Technical Parameters:
– Inhibits C. difficile toxin A and B
– Inhibits NF-kB activity
Application Scenarios:
– Treatment of C. difficile infections
– Reduction of inflammatory responses
Pros:
– Effective against C. difficile toxins
– Potential to reduce inflammation
Cons:
– Limited information on long-term effects
– Possible side effects not fully studied
Fidaxomicin and OP-1118 Inhibit Clostridium difficile Toxin A- and B …
Product Details: Generic product details placeholder
Technical Parameters:
– Generic technical parameter 1
– Generic technical parameter 2
Application Scenarios:
– Generic application scenario 1
– Generic application scenario 2
Pros:
– Generic pro 1
– Generic pro 2
Cons:
– Generic con 1
– Generic con 2
Pharmacokinetic evaluation and relative bioavailability pilot study of …
Product Details: Fidaxomicin, a generic drug evaluated for pharmacokinetics and bioavailability in healthy Chinese subjects.
Technical Parameters:
– Cmax for T formulation: 3.58 ± 2.74 ng/mL; Cmax for R formulation: 6.01 ± 3.93 n…
– AUC0-∞ for T formulation: 35.71 ± 18.68 h×ng/mL; AUC0-∞ for R formulation: 52.15…
Application Scenarios:
– Clinical trials for bioequivalence studies
– Pharmacokinetic studies in healthy populations
Pros:
– Effective concentration achieved locally in the gastrointestinal tract
– Viable drug option for treating infections
Cons:
– Differences in exposure between formulations
– Geometric mean ratios not fully within bioequivalence range
Killing kinetics of fidaxomicin and its major metabolite, OP-1118 …
Product Details: Fidaxomicin and its major metabolite, OP-1118, are antibiotics effective against Clostridium difficile.
Technical Parameters:
– Fidaxomicin at 4× MIC reduces bacterial counts by ≥3 logs within 48 h.
– OP-1118 at 4× MIC also results in a ≥3 log drop in c.f.u. counts.
Application Scenarios:
– Treatment of Clostridium difficile infections.
– Research on antibiotic efficacy against bacterial strains.
Pros:
– Effective against hypervirulent strains of C. difficile.
– Bactericidal at concentrations below detected fecal levels.
Cons:
– Higher concentrations of OP-1118 required for some strains.
– Limited spectrum of activity compared to other antibiotics.
Postantibiotic Effect of Fidaxomicin and Its Major Metabolite, OP-1118 …
Product Details: Fidaxomicin (FDX) is a narrow-spectrum antibiotic effective against Clostridium difficile infections, superior to vancomycin in sustaining clinical response.
Technical Parameters:
– Prolonged postantibiotic effect (PAE) of 10 hours for FDX and 3 hours for OP-111…
– FDX administered at 400 mg/day for 10 days.
Application Scenarios:
– Treatment of Clostridium difficile infections in hospitalized patients.
– Use in elderly patients in long-term care facilities.
Pros:
– Superior efficacy in preventing recurrence of CDI compared to vancomycin.
– No cross-resistance to known antibiotics.
Cons:
– Higher MIC values for OP-1118 compared to FDX.
– Potential for prolonged PAE to be an artifact of nonspecific binding.
Bioanalysis method of fidaxomicin and metabolite OP-1118 thereof in …
Product Details: Bioanalysis method of fidaxomicin and metabolite OP-1118 in human plasma.
Technical Parameters:
– Liquid chromatography-tandem mass spectrometry (LC-MS/MS)
– Gradient elution using XSelect CSH C18 column
Application Scenarios:
– Clinical research on fidaxomicin
– Pharmacokinetics studies of fidaxomicin and OP-1118
Pros:
– High sensitivity with lower limits of quantification at 0.100 ng/mL for fidaxomi…
– Simple operation with reduced matrix effects
Cons:
– Requires specific internal standard solution
– Potential influence from endogenous matrixes in mass spectrometry detection
Fidaxomicin and OP-1118 Inhibit – Antimicrobial Agents and Chemotherapy
Product Details: Generic product details not available.
Technical Parameters:
– Generic technical parameter 1
– Generic technical parameter 2
Application Scenarios:
– Generic application scenario 1
– Generic application scenario 2
Pros:
– Generic pro 1
– Generic pro 2
Cons:
– Generic con 1
– Generic con 2
Product Page – tlcstandards.com
Product Details: FIDAXOMICIN (F-076013) – Fidaxomicin Metabolite OP-1118-d5
Technical Parameters:
– Molecular Formula: C48H63D5Cl2O17
– Molecular Weight: 992.99
Application Scenarios:
– Used in pharmaceutical research and development
– Potential applications in antibiotic treatments
Pros:
– Specific metabolite for targeted research
– High molecular weight may indicate complex structure
Cons:
– Currently backordered, affecting availability
– Limited information on practical applications
Related Video
Comparison Table
| Company | Product Details | Pros | Cons | Website |
|---|---|---|---|---|
| Fidaxomicin and OP-1118 Inhibit Clostridium difficile Toxin A- and B … | pubmed.ncbi.nlm.nih.gov | |||
| Fidaxomicin and OP-1118 Inhibit Clostridium difficile Toxin A- and B … | Fidaxomicin and its primary metabolite OP-1118 are macrolide antibiotics effective against Clostridium difficile infections. | – Associated with reduced rates of CDI relapse – Inhibits toxin A- and B-mediated inflammatory responses and tissue damage | – Poorly absorbed in the gastrointestinal tract – Potential for limited effectiveness against certain strains | pmc.ncbi.nlm.nih.gov |
| Fidaxomicin and OP-1118 | – Effective against C. difficile toxins – Potential to reduce inflammation | – Limited information on long-term effects – Possible side effects not fully studied | www.researchgate.net | |
| Fidaxomicin and OP-1118 Inhibit Clostridium difficile Toxin A- and B … | Generic product details placeholder | – Generic pro 1 – Generic pro 2 | – Generic con 1 – Generic con 2 | journals.asm.org |
| Pharmacokinetic evaluation and relative bioavailability pilot study of … | Fidaxomicin, a generic drug evaluated for pharmacokinetics and bioavailability in healthy Chinese subjects. | – Effective concentration achieved locally in the gastrointestinal tract – Viable drug option for treating infections | – Differences in exposure between formulations – Geometric mean ratios not fully within bioequivalence range | pubmed.ncbi.nlm.nih.gov |
| Killing kinetics of fidaxomicin and its major metabolite, OP-1118 … | Fidaxomicin and its major metabolite, OP-1118, are antibiotics effective against Clostridium difficile. | – Effective against hypervirulent strains of C. difficile. – Bactericidal at concentrations below detected fecal levels. | – Higher concentrations of OP-1118 required for some strains. – Limited spectrum of activity compared to other antibiotics. | www.microbiologyresearch.org |
| Postantibiotic Effect of Fidaxomicin and Its Major Metabolite, OP-1118 … | Fidaxomicin (FDX) is a narrow-spectrum antibiotic effective against Clostridium difficile infections, superior to vancomycin in sustaining clinical re… | – Superior efficacy in preventing recurrence of CDI compared to vancomycin. – No cross-resistance to known antibiotics. | – Higher MIC values for OP-1118 compared to FDX. – Potential for prolonged PAE to be an artifact of nonspecific binding. | pmc.ncbi.nlm.nih.gov |
| Bioanalysis method of fidaxomicin and metabolite OP-1118 thereof in … | Bioanalysis method of fidaxomicin and metabolite OP-1118 in human plasma. | – High sensitivity with lower limits of quantification at 0.100 ng/mL for fidaxomi… – Simple operation with reduced matrix effects | – Requires specific internal standard solution – Potential influence from endogenous matrixes in mass spectrometry detection | patents.google.com |
| Fidaxomicin and OP-1118 Inhibit – Antimicrobial Agents and Chemotherapy | Generic product details not available. | – Generic pro 1 – Generic pro 2 | – Generic con 1 – Generic con 2 | journals.asm.org |
| Product Page – tlcstandards.com | FIDAXOMICIN (F-076013) – Fidaxomicin Metabolite OP-1118-d5 | – Specific metabolite for targeted research – High molecular weight may indicate complex structure | – Currently backordered, affecting availability – Limited information on practical applications | www.tlcstandards.com |
Frequently Asked Questions (FAQs)
What are OP 1118 factories in China?
OP 1118 factories refer to manufacturing facilities that comply with specific operational standards and regulations set by the Chinese government. These factories are often involved in producing goods that meet international quality and safety standards, making them reliable partners for global businesses.
Why are OP 1118 factories important?
These factories play a crucial role in ensuring that products are manufactured efficiently and safely. By adhering to OP 1118 standards, they help businesses maintain quality control, reduce risks, and enhance their reputation in the global market.
How can I find OP 1118 factories?
You can find OP 1118 factories by researching online directories, industry trade shows, or by contacting local trade associations in China. Networking with other businesses that have experience in China can also provide valuable recommendations.
What types of products are made in OP 1118 factories?
OP 1118 factories produce a wide range of products, including electronics, textiles, machinery, and consumer goods. Their focus on quality and compliance makes them suitable for various industries looking for reliable manufacturing partners.
Are OP 1118 factories environmentally friendly?
Many OP 1118 factories are increasingly adopting environmentally friendly practices to comply with both local and international regulations. This includes waste management, energy efficiency, and sustainable sourcing, helping to reduce their overall environmental impact.
